Drugs with side effects in the ANS

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Table 1.


Drug 1: Prazosin

Drug 2: tamulosin

Side effects




Orthostatic hypotension and syncope 

Orthostatic hypotension and syncope

Why does side effect happen




This drug causes the side effects by competitively blocking the α1-adrenaergic receptors. This effect leads to dilation of both blood vessels. Arguably, the hypotension occurs as more blood collects in the limbs as one stands up (Lehne, 2013).

The drug cause the orthostatic hypotension by blockade of α1-adrenergic receptors, causing vasodilatation of veins and arteries (Lehne, 2013).

How can the side effect be managed?


The orthostatic hypotension can be managed by instructing patients to sit or lie down. The effects can also be minimized by telling patients to move slowly when changing positions from sitting to upright (Lehne, 2013).

As with prozasin, the side effects from doxazosin cause relates to the first dose. However, the effects can be managed by administering the initial dose during bedtime (Lehne, 2013).

Anti-cholinergic burden score

Anti-cholinergic burden refers to the cumulative effect of taking many medicines with anti-cholinergic activity. Prozasin does not have an anti-cholinergic effects as it does not interact with cholinergic receptors.

Equally, dozaxosin does not have an anti-cholinergic burden because it does not interact with anti-cholinergic receptors.














Reference List

Lehne R, 2013, Pharmacology for nursing care, 8th edition, New York: Elsevier

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